Stefano made many enemies during his time in Salem.
However, he wasn’t the sole reason for the pain and misery suffered by several of the characters.
So much has happened to so many over the years.

Marlena was introduced to fans in 1976 and she’s been one of the most tormented characters ever since.
Marlena later married Roman Brady (then Wayne Northrop) and welcomed twins Sami and Eric.
Stefano even used Marlena to give birth to Rex and Cassie Brady, who were genetically engineered twins.

She became possessed again decades later.
Eventually, John was believed to be Marlena’s presumed-dead husband Roman Brady.
John lived as Roman for years and fell madly in love with Marlena.

After moving on from Marlena, John met Isabella Toscano and the couple tied the knot.
John and Marlenaeventually got back together and even wed, but John still had questions about his past.
He found information revealing that he had been adopted by the Alamain family and given the name Forrest Alamain.

However, that was later debunked.
John has created a life and family in Salem.
However, he’s never truly found out who he is or where he came from.

Longtime “Days of Our Lives” fans have watched the character grow up.
Teenage Hope met Bo Brady and fell head over heels in love.
As an adult, Hope was often a target of Stefano DiMera.

She was kidnapped multiple times and even brainwashed to believe she was an art thief named Princess Gina.
Over the years,Bo and Hopewelcomed three children together.
Later, Hope watched Bo die in her arms after he was diagnosed with a brain tumor.
Abby lived a very dramatic life, starting with a serious illness as a baby.
She also dealt with her father being presumed dead on several occasions.
Abby was engaged to Ben when it was discovered that he was a serial killer.
She was also pregnant with a child she believed to be his.
Abby eventually began having serious mental health issues, including delusions.
After getting help,Abby and Chadwelcomed a daughter.
However, their time together was limited.
The character was once believed to be the son of Stefano DiMera and the identical half-brother ofAndre DiMera.
Eventually, it was revealed that he was completely betrayed by his would-be father and brother.
Stefano arranged for Tony to be kidnapped and placed on a deserted island.
After finally returning home, Tony told his story and even reconciled withthe love of his life, Anna.
Of course, Tony wasn’t really dead, and he was brought back by Dr. Rolf’s serum.
Sadly, all of Tony’s presumed deaths cost him decades of his life.