The iconic pairing started in the ’90s with the movie “Clerks” (viaMovie Web).
The chemistry between the two actors on film is undeniable.
They create comedy gold (per The Things).

Fans of the duo’s films would be happy to know that the chemistry isn’t just acting.
The pair have a beautiful friendship in real life.
Mewes struggled with an addiction that interfered with their working and personal relationship.

Smith and Mewes have gone down in comedy history as a fan favorite duo.
Outside of filming, they are best friends whose chemistry exists far beyond the lines of a movie!