The show has offered such tragic scenes as the deaths of lead characters George O’Malley (T.R.
When the show was still in its infancy, Izzie and Denny’s doomed romance dominated the storyline.
During Season 2 of the medical drama, Denny was admitted to the hospital as a heart transplant patient.

He and Izzie immediately hit it off and fell in love during his hospital stay.
Finally, after Denny was able to have surgery, Izzie was there by his side.
The two planned their lives together, but a complication led to Denny’s devastating death.

Before heading to the prom, Izzie stopped by Denny’s hospital room to show off her dress.
However, she found Denny dead in his bed.
“I wanted it to feel the way it was written on the page,” Heigl stated.

And the worst was that I really went there," she continued.
“I was 7 when my brother died but we were in the hospital for a week.
The actor dealt with rumors of bad blood between her and the show’s creator, Shonda Rhimes.
And I just kind of fled in a panic,” Heigl told Bevy Smith during aSiriusXM interviewin 2022.
“I was breaking, it was breaking me, and I was young,” she stated.
However, looking back, the “Firefly Lane” star admitted that she would do things differently.
Taken a breath, thought it through, had some conversations.'"