From 1996 to 2002, O’Donnell hosted “The Rosie O’Donnell Show.”
One of her guests was fellow comedian and good friend Ellen DeGeneres.
However, the friendship between O’Donnell and DeGeneres eventually fizzled out.

It’s a big transition.
But we’ve had our weirdness in our relationship.
We’re not friends."

O’Donnell told The Hollywood Reporter that DeGeneres apologized, but that she has no plans to rekindle the friendship.
I have compassion, even though, you know, I hear the stories and I understand.
I think she has some social awkwardness" (viaPeople).