Christina Applegate is one of the most beloved sitcom actresses, with a career that spans over five decades.

Sadly,Applegate’s health struggleseventually forced her to quit acting.

The “Married … with Children” star underwent several surgeries following a breast cancer diagnosis in 2008.

Christina Applegate’s Walk of Fame ceremony

She also experienced insomnia for two decades, which left her feeling drained.

Applegate first felt that something was wrong while filming the first season of “Dead to Me.”

The actress started to lose her balance, but she didn’t think much about it.

Christina Applegate and Selma Blair

At some point, she mentioned her symptoms to Selma Blair, who encouraged her to seek help.

“She said, ‘You must get tested for MS,'” the actress added.

Applegate and Blair starred together in the 2002 comedy film “The Sweetest Thing.”

Selma Blair and Christina Applegate

Unfortunately, she turned out to be right about her friend’s diagnosis.

After undergoing several tests, Applegate found out she had MS and everything started to make sense.

“I couldn’t walk.

They had to use a wheelchair to get me to set.

I was freaking out,” Applegate recalled.

For this reason, itoften goes undiagnosed.

With that in mind, Christina Applegate and Selma Blair are trying to raise awareness of the disease.

“I do think representation matters.

The “Married … with Children” stars joined forces withNeo Walk, a brand of mobility aids.

Together, they designed a clear acrylic cane, with 5% of the profits going to MS research.

Applegate got involved in this project as part of her efforts to help those living with multiple sclerosis.

Her health condition also brought her closer to Blair, cementing their friendship.

“She’s such a nurturer.

If you need something, she’s at your house,” Blair confessed in an interview withEntertainment Tonight.

Applegate is currently trying to get her life back on track.

She also hired a weekend caretaker to help her around the house.

“I like to keep it as quiet and mellow as possible,” she told Vanity Fair.

Although she doesn’t plan to act on camera again, she’s open to voiceover roles.