Premiering on FOX, “House, M.D.”

The long-standing NBC drama “E.R.”

“It never occurred to me that it would have this sort of following and this sort of excitement.

Hugh Laurie of House, M.D

It’s been amazing.”

Laurie would go on to be nominated for six Emmys and win a Golden Globe for his performance.

Laurie stepped (uh, limped) into the role of the arrogant doctor with a humbler approach.

Hugh Laurie in character/smiling for camera

“He was a very gentle soul and, I think, a very good doctor.

And I’m probably being paid more to become a fake version of my own father.”

He’d also appear in crossover episodes for sister-shows “Chicago P.D.”

Jesse Spencer in character/smiling for camera

and “Chicago Med.”

Cameron would exit in Season 6.

Shortly after, she picked up a recurring cast member credit in “This is Us.”

Jennifer Morrison in character/ posing for camera

Morrison would later make her feature directorial debut in the Netflix film “Sun Dogs.”

I really enjoy being able to problem solve in that position."

She’d later return behind the camera to direct an episode of HBO’s critically-acclaimed series “Euphoria.”

Omar Epps in character/posing for camera

you’ve got the option to catch Morrison in ABC’s upcoming drama series “Will Trent”.

After much reconsideration, he’d later rejoin House’s team.

Omar Epps had no doubt in his mind that the show would be a worldwide hit.

Leonard in character/smiling for camera

“The thing I would say to international viewers is, watch the show.

Epps would laterreunitewith House alum Jennifer Morrison for a few episodes in “This is Us.”

Regarding hanging up his stethoscope and moving on,Leonard said, “I feel great.

Edelstein in character/ posing for camera

It’s very much like summer when you’re in school and it starts getting warmer.

I like jobs ending, it feels good to me …

I’m excited about moving on.”

Jacobson in character/ posing for camera

Cuddy would make a sudden exit after Season 7.

The real reason behind actress Lisa Edelstein’s sudden exit from the series was reportedly a dispute in pay.

As a result, she bowed out for the final season.

Wilde in character/ smiling for camera

“It was very sad and very disappointing and a really difficult decision to make.

From that point onward, he remained as a major character throughout the rest of the show’s run.

Which also meant that I, the actor, would essentially be auditioning through all those episodes.

Penn in character/ in candid shot

This seemed like it might be pretty stressful for me,“Peter Jacobson sharedregarding his initial casting thoughts.

“A couple weeks later, I heard I got the gig.”

And we all probably felt some of the exhaustion from being on it that long.

Dudek in character/smiling on red carpet

So I was kind of ready to move on.”

His latest project has been a recurring role in “Fear the Walking Dead.”

“We’re very proud of her and very happy for her.”

Regarding her departure, Wilde toldEW, “I had such an amazing run on the show.

They’ve done such cool things with my character.

She’s been so fascinating, dynamic and cool and unpredictable.”

She recently made her directorial debut in the coming-of-age film “Booksmart.”

Her next directorial project is the upcoming “Don’t Worry Darling.”

Kal Penn (Lawrence Kutner)

Dr. Lawrence Kutner joined House’s team in Season 4.

His exit from the show unfolded in atragic twist, leaving viewers startled.

Alater encounterwith incoming First Lady Michelle Obama would then expedite that system process.

Her delicate pearls and blonde locks suggested innocence and grace, which Amber was everything but.

Amber would tragically exit in a Season 4 finale thatfans wouldn’t ever forget.

She’s going to go down in flames, but at least it’s going to be fun.'

But I think there weren’t a lot of characters like that on prime-time television shows.