Still going strong, Season 20 is expected to premiere sometime in 2024.

Paging Dr. Stevens and Dr. Karev

From the moment Alex Karev met Izzie Stevens, sparks flew.

Sure, they bickered, but that was all part of their chemistry and their charm.

cast members of Grey’s Anatomy being goofy

They kissed, and we swooned.

They broke up, and we cried.

They got married, and we thought they were destined to be together forever.

Alex and Izzie happy in scrubs

But then those pesky actors got in the way.

Katherine Heigl left “Grey’s Anatomy"in Season 6, taking Izzie with her.

Is it any wonder fans of the show voted for Izzie and Alex to have their spinoff series?

April and Jackson sweetly cuddling

Jackson (and his portrayer Jesse Williams) stayed until Season 17.

Another reason fans want to see Jackson and April in Boston?

The potential for familiar guest stars.

As one pollster pointed out.

Your move, Shonda Rhimes.